Around the world, people suffer more from pain due to the fact that their immune systems cannot discern between healthy cells from invader microorganisms. Organs and tissues are now being attacked by the disease defenses that they once had.
Research efforts across the globe are intensifying to combat this trend. An instance is the London Francis Crick Institute initiative which James Lee and Carola Vinesa who are world-renowned experts in this field, have created distinct research groups that will assist in determining the exact nature of the autoimmune disorders.
Lee explained to the Observer that autoimmune illnesses began to increase about 40 years ago, in western nations. There are new cases in countries where these conditions have never been seen before.
For example, the biggest recent increase in cases of inflammatory bowel disease is in the Middle East and east Asia. They'd never heard of this disease before.
Type 1 diabetes is one of the autoimmune disorders. Other diseases include rheumatoid disease, inflammatory bowel and multiple sclerosis. In all cases, the immune system focuses on healthy tissue and not the infective agents.
The UK has at least 4,000,000 people who have these conditions. There are numerous other. According to international estimates, the number of patients suffering from autoimmune disorders is on the rise by between 3% - nine percent per year. Researchers believe that environmental triggers play a major role in this rise.
Lee, who was previously in Cambridge University, says that human genetics hasn’t changed over the last decade. There must be a change in the outside world in a way that is increasing our susceptibility to autoimmune disease.
Vinuesa supported the idea, having previously worked at the Australian National University. She cited changes in diet that were taking place as more countries adopted western-style diets , and people ate more fast food.
Vinuesa said that fast food meals lack some important ingredients such as fiber. The evidence suggests that this change could affect a person's microbiome that is the collection of microorganisms that reside in our digestive tract. Microorganisms play a vital role in regulating many bodily functions.
Changes in our microbiomes can trigger autoimmune disease, of which more than 100 have been diagnosed.
The two scientists also stressed that every person is at risk of developing these illnesses, which include celiac, Lupus, and various other illnesses, such as celiac, which cause inflammation and swelling and may cause severe harm to different organs.
Vinuesa states that a person who does not have a particular genetic susceptibility to develop an autoimmune disorder, regardless of the quantity of Big Macs they eat. "There isn't much that we can do to stop the worldwide spread of fast-food franchises. Instead, we are focusing in understanding the genetic mechanisms that underlie autoimmune disorders and how some people are more susceptible to the disease while others are not. This is the stage at which we intend to tackle this issue."
Because of the advancement of technology, researchers are now able to find small differences in people's DNA. This allows them to identify common genetic patterns that are common to people with an autoimmune disorder.
Lee stated that up until recently , we did not have the tools necessary to analyze DNA. Now, we're blessed with this incredible power and it has changed everything. When I began my studies, we were aware of fifty DNA variants that could trigger inflammatory bowel disease. Today, we have more than 250.
This is at the center of Lee's and Vinuesa’s work. They seek to determine how different genetic pathways function and uncover the various types of diseases doctors are currently studying. Vinuesa has stated that there are a variety of variations of autoimmune diseases, such as Lupus. This can make it challenging to determine the best treatment.
There are numerous effective new therapies in development, we don't yet know the people they ought to be given to. This is due to the fact that we don't really know the specific type of illness. This is the purpose of autoimmune research. We have to learn how to categorize and stratify patients, so that we can provide them with the appropriate therapy.
Lee stressed that the rising prevalence of autoimmune diseases across the world meant that Read More new treatment and drugs were needed urgently. There are currently no cures for autoimmune diseases that usually manifest in young people - while they are trying to complete their education, get their first job, and start families, Lee said.
This means that more people will need surgeryor require regular injections for the rest their lives. This can be very difficult for rheumatoid arthritis physiopedia patients as well as a huge burden on healthcare services. It is therefore essential to find effective and new treatments.
Rheumatoid arthritis is an auto-immune disease, meaning it's caused by the immune system attacking healthy body tissue. It's unclear what causes this.
The immune system typically produces antibodies that fight bacteria and viruses to combat infection.
If you suffer from Rheumatoid arthritis, your immune systems mistakenly releases antibodies into your joint the lining of your joints, and they target the tissues around them.
The delicate layer of cells (synovium) that cover your joints, is prone to inflammation and sore.
bones
Cartilage is the connective tissue between bones which is made up of cartilage.
Tendons connect bone to muscles
ligaments - the tissues that connects bone and cartilage
If the problem isn't treated, it can gradually result in the loss of joint alignment and form. The chemicals may eventually cause the destruction of the entire joint.
While there are many theories on why the immune system targets joints, none has been proved.
Possible risk factors
There are a variety of factors that may increase your risk of developing rheumatoid arthritis, for example:
The genes. There are some indications that arthritis rheumatoid may be a family trait. But, because genes play a tiny part in the condition's development and progression, there's a low chance that the condition will be transferred to the next generation.
Hormones Rheumatoid Arthritis are more common in women than it is for men. It could be due to the effects of the hormone Oestrogen. However, this link has yet to be proven.
smoking - some evidence suggests that people who smoke are at a higher risk of developing rheumatoid arthritis